Mast cell activation in long COVID involves an abnormal immune response where mast cells release excessive inflammatory mediators, leading to symptoms like fatigue, brain fog, and gastrointestinal issues. This condition can exacerbate long COVID symptoms, contributing to chronic inflammation and multisystem involvement. Management includes antihistamines, mast cell stabilizers, and personalized treatment plans to reduce inflammation and improve patient outcomes.
Mast cell activation, a key component of the immune system, has been increasingly recognized as a significant contributor to the symptomatology of Long COVID. Mast cells play a crucial role in the body’s defense against pathogens and in regulating allergic responses and can manifest as persistent fatigue, brain fog, headaches, gastrointestinal issues, skin rashes, joint