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Biomarkers Latest Research | Long Covid ME/CFS

*** Research | CD8 T-Cell Function ME/CFS & Long Covid

Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series

Summary:

The research focused on evaluating the response to nebulized antioxidant/anti-pathogen treatment in patients with ME/CFS and Long COVID. Eight patients from the UMass Chan Medical School study underwent this treatment and consented to be part of a retrospective case series.

The study assessed changes in T-cell immune response and symptoms in these patients over 15 months. Findings indicated improvements in CD8 T-cell function and decreased symptom severity ratings. The study aimed to understand the similarities between ME/CFS and Long COVID, develop diagnostic biomarkers, and explore the therapeutic potential of the nebulized agent.

The research highlighted the importance of early intervention in Long COVID to potentially reverse the disease course and improve patient outcomes. Funding for the study was provided by various sources, including NIH and private donations. The study contributes to advancing the understanding and management of ME/CFS and Long COVID through immune system modulation and symptom alleviation.

  • Patients’ Response to Treatment:
    • LC Patient 1 experienced symptom exacerbation post-COVID vaccine but improved with nebulized treatment.
    • 6 other patients showed symptom improvement with nebulized therapy.
  • Immune Dysregulation Findings:
    • CD8 T-cell dysfunction observed in ME/CFS and Long COVID patients.
    • Potential immunological biomarker for diagnosis and monitoring identified.
  • Therapeutic Potential:
    • Nebulized agent showed positive response in all patients.
    • Early intervention in Long COVID may reverse disease course.
  • References:
    • Studies on ME/CFS, immune system dysregulation, and antiviral treatments discussed.

Main Points:

  • LC Patient 1 improved with nebulized treatment post-COVID vaccine.
  • 6 patients showed symptom improvement with nebulized therapy.
  • CD8 T-cell dysfunction observed in ME/CFS and Long COVID patients.
  • Potential immunological biomarker identified for diagnosis and monitoring.
  • Nebulized agent showed positive response in all patients.
  • Early intervention in Long COVID may reverse disease course.

Early intervention with nebulized therapy in Long COVID patients shows promising results in symptom improvement and potential disease course reversal.

Long Covid The Answers

Credible Source:

Gil A, Hoag GE, Salerno JP, Hornig M, Klimas N, Selin LK. Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series. Brain, Behavior, & Immunity-Health. 2024 Mar 1;36:100720.